LipoTrue - IN SILICO & BIOMIMETIC DESIGN OF PEPTIDES
WASPILK™
Biomimetic peptide for hair and skin
Waspilk™ is a biomimetic peptide that integrates this spider lifeline silk design. It enhances the structural strength of skin and hair by increasing cytokeratin and keratins, promoting regeneration, and improving collagen synthesis and organization through key matricellular proteins such as SPARC. These lead to a more cohesive and resilient skin structure
At the same time, Waspilk™ improves elastic resilience by reinforcing elastic fibers and dermal organization, while also enhancing hair elasticity and resistance
These improvements deliver firmer, more elastic and smoother skin with reduced wrinkles, while also promoting a re-contouring effect for an improved facial definition. Hair becomes stronger, more vital and resilient, alongside a healthier scalp.
RESULTS:
✓ +7.3% elasticity and +6.2% firmness in 28 days
✓ Up to -2.3 mm in re-contouring after 24 h
✓ -6.2% wrinkle volume after 7 days
✓ Up to 20% less roughness after 7 days
✓ +72% more hair root radiance after 14 days
✓ 59% of the volunteers showed a scalp improvement in 24 h
✓ Up to 54% less hair shedding in 56 days
CELLAIGIE™
Unlocking metaTORphosis
Cellaigie™ is an AI-designed peptide that biohacks aging through Autophagic Intelligence, targeting mTOR to guide cells into metaTORphosis, a transformative resting state where cells prioritize renewal, enhance clearance, and optimize longevity
By mimicking key fasting benefits at the cellular level, Cellaigie™ enhances autophagy, regulates glycogen storage and reduces senescence markers. It helps improve skin luminosity, smooth wrinkles, and boost rejuvenation, firmness, and elasticity, redefining smart skincare.
RESULTS:
✓+14% antioxidant capacity (optimized efficiency) in 28 days
✓ Up to 26% more luminosity & 30% less wrinkle depth after 12 h cell fasting induced with Cellaigie™
✓ +26.0% luminosity & -12.9% wrinkle depth in 28 days
✓ Almost 3 years younger after 12 h cell fasting induced with Cellaigie™
✓ Almost 6 years younger after 28 days
✓ +9.5% & +10.6% elasticity and firmness in 28 days
SP[AI]3™
Smart peptide for sebum, pore, inflammation
SP[AI]3TM is a unique peptide obtained in silico through AI among thousands of candidates, with optimal binding and specificity, to modulate not just one, but three key players: sebum, pore, inflammation
This triple specific targeting of SP[AI]3TM ensures a complete approach revealing a decrease in both sebum synthesis and quantity, as well as a reduction in pore size, and obstruction, while also demonstrating a decrease in C. acnes-induced inflammation.
In Vivo, SP[AI]3TM provided a holistic approach with rapid results, revealing an improvement of skin imperfections, protoporphyrins, pore size, and sebum production, for a purified skin.
RESULTS:
✓ -19% pimples in 14 days
✓ –8% pore size in 28 days
✓ Up to 39% less sebum in 7 days
IPEPTIDE™
A good beauty sleep
iPeptide™ attenuates the exaggerated inflammatory response of the alarmin, IL-33. It prevents damage induced by sleep deprivation, presents melatonin-like properties against glycation & peroxidation and reinforces the first line of immune defense.
Right now, it is time to start biohacking your sleep.
RESULTS:
✓ +9% eye awakening in 68% of volunteers after one month
✓ -5% fatigue signs in only a week
✓ -7% eyebags in 2 weeks vs placebo
✓ -0.96ºC (-33.7ºF) local skin temperature in 91% of volunteers in 1 hour
✓ -12% & -19% dark circles in 7 and 28 days
MUNAPSYS™
Choose your expression
Munapsys™ is a botulinum toxin-like peptide obtained by in silico design in collaboration with experts in neuroscience. It is the first cosmetic ingredient able to act both in the pre- and post-synaptic pathways of muscle contraction and in a new SNARE protein (Munc-18).
Munapsys™ mechanism is a real upgrade in the expression lines field, with proven efficacy compared with a benchmark combination even at a lower dose.
RESULTS:
✓ Up to 37.6% less depth of the biggest wrinkle in 7 days
✓ +31% volunteers showing efficacy in Rt with 3% Munapsys™ than with 5% benchmark at 14 days
✓ Up to 16.7% happier smile (lifting of commissures)
N_LLSCENT™
The purity of your natural essence
Sebaceous and sweat glands secretions and skin waste are metabolized or oxidized to Volatile Organic Compounds (VOCs) such as 2-nonenal and isovaleric acid. N_llscent™ immediately gets rid of the isovaleric acid smell from feet and armpits and of 2-nonenal from the neck and the belly.
RESULTS:
✓ Isovaleric acid smell went from moderate to slightly perceptible after 30 min
✓ -39% and -24% isovaleric acid smell due to sweat in armpit and foot after half an hour
✓ 93% volunteers enjoyed a reduction of the 2-nonenal odor in neck & belly in 30 min
✓ -36% and -39% 2-nonenal smell in neck and belly after 30 min
✓ -32% lipid peroxidation (MDA) in 77% volunteers at 21 days
NEØCLAIR PRO™
Come to the clear side
Detoxified skin is clear, while too many toxins lead to dark spots/ hyperpigmentation, aging signs, inflammation, dullness and loss of elasticity. Neøclair Pro™ is a primary antioxidant peptide which also acts as an antioxidant amplifier via NRF2/ARES pathway.
Neøclair Pro™ offers 360° antipollution protection and repair (outdoor. indoor. internal), visibly lightening dark spots and improving brightening and aging and inflammaging signs. Come to the clear side and escape the city within the city
RESULTS:
✓ Up to 7 ITAº in skin color and 12 ITAº in dark spots in 28 days
✓ Up to 20% less lipid peroxidation in 1 month
SKINARCH™
The art of building collagen
Skinarch™ increases Mohawk, a novel key player in the cosmetic field, which may be considered the architect of the skin, promoting the formation of new & well-organized collagen I & III fibers for a proper biotensegrity. Skinarch™ also works on the four collagen families: fibrillar collagens, connecting and anchoring collagens, network-forming collagens and collagen-like membrane proteins.
Moreover, its inclusive efficacy on skin architecture against wrinkles and sagging was proved in a mixed panel of volunteers with light-pigmented (phototype II-III) and dark-pigmented (phototype V-VI) skin.
RESULTS:
✓ Up to 29% (V-VI) and 21% (II-III) less wrinkle depth in 56 days
✓ Improvement in face architecture (full face lifting & plumping effect in 56 days)
✓ -2 mm total length evolution of face in 56 days
STELLIGHT™
A lightening constellation
Stellight™ is a smart creation of a synthetic hexapeptide which has a unique activity on melanocytes, keratinocytes and fibroblasts, inhibiting their three-way communication.
Moreover, it inhibits the production of melanin, reduces the number of dendrites and has an antioxidant effect.
RESULTS (After 56 days vs placebo):
✓ Forehead
+8% ITA
+25% Luminosity
✓ Eyelid
+5-fold ITA
+2-fold Luminosity
✓Nasolabial area
+15% ITA
+46% Luminosity
✓Eye contour area
+34% ITA
+27% Luminosity
✓Lip’s corner
+56% ITA
+71% Luminosity
✓Cheeks dimple
+11% ITA
-33% Luminosity
Telessence Telmeric™
Envirostress turmeric peptide
Telessence Telmeric™ soothes the Envirostress damage response activated by the TLR2 signalling pathway, alleviating the NF-kB response and, hence, relieving inflammation, which is also reduced by the action of miRNAs.
Telessence tackles the 3 types of stress that accelerate biological aging: environmental (Envirostress), physical (Phystress) and emotional (Emostress). 3 actives, 3 technologies, 3 stresses, 1 essence.
RESULTS:
✓ More resilience to temperature changes (less redness, less reactivity)
✓ Up to 10% less pore size after 7 days
✓ Up to 23% less desquamation after 28 days
✓ +7% skin smoothness in 30 minutes
✓ Up to 18% less skin roughness after 28 days
V-4s™
Feeling totally secure
V-4s™ protects our skin from the main four radicals. V-4s™ decreases the levels of reactive oxygen species (ROS) induced by H2O2 and ozone, scavenges sulfur (RSS) and nitril species (RNS), and protects against lipid-peroxidation-derived reactive carbonyl species (RCS).
PRODUCT APPLICATIONS:
✓ AntiRadical TECHnology with a transversal application
✓ We will be invincible-“V”-meaning “victory, liberty”
✓ Protection of skin care formulations
✓ Environmental protection
✓ Wide-ranging antioxidant action in one product
✓ Antiaging, Sensitive skin, Acne, Brightening & Sunscreen products
VERSILLIN™
Repositioning your beauty
Versillin™ boosts the fibrillin-versican-hyaluronan elastic-hydrated matrix, reinforcing the connective tissue of the dermis and the beauty columns (skin ligaments) to anchor and fasten the skin.
The overall benefit is an increase in firmness and viscoelasticity to reposition the beauty columns into their original position.
RESULTS:
✓ Up to 52 and 48 mm3 less jowls sagging at 14 and 28 days
✓ –20% and –14% deformation and flaccidity after 56 days
POPTIDE™
Organizing skintropy
Poptide™ is a cyclic peptide that organizes skintropy by raising BiP and calreticulin (folding optimizers) in the endoplasmic reticulum improving protein folding.
Poptide™ acts on the WDC by reducing morning & evening wrinkles, redefining the wrinkle’s daily fluctuation.
RESULTS:
✓ -33% reduction of the gap between morning & evening depth after 28 days
✓ -10% less wrinkle’s depth both in the morning and evening
✓ Up to -14% less wrinkle’s volume at 28 days both in the morning and evening
✓ Up to +12% more evening skin thickness
LipoTrue - WILD PLANTS AS BIOFACTORIES
CO///A3™
Cushiony radiant baby-like skin
CO///A3™, a biomimetic fragment of human collagen III transiently expressed in wild plantsgrown through vertical farming, helps reactivate lost key functions for a smoother, cushioned and naturally luminous skin
Acting through three coordinated pillars, CO///A3™ rebuilds the matrix by boosting collagens I, III and elastin while supporting structural stabilization; it restores baby‑skin identity by shifting integrins toward a younger profile; and it reprograms cellular behaviourby enhancing ECM coordination through lumican and the matricellular protein TSP4
CO///A3™ brings back the baby‑like skin, restoring its natural glow, redensifying the dermis, increasing firmness and elasticity, and smoothing roughness and wrinkles.
RESULTS:
✓ +7.2% & +14.8% collagen vs T0 and placebo after 56 days
✓ Up to 45% more collagen in 2 months
✓ +32.5% gloss in 30 minutes
✓ Up to 24% more dermal density in 28 days
✓ Up to 17% & 16% more firmness and elasticity in 1 week
✓ -6.8% & -4.8% wrinkle depth & roughness after 1 month
KERADUO™
Vegan keratin-collagen tandem
Keraduo™ merges the structural reinforcement of keratin 31 to repair, protect, and reduce cuticle porosity with collagen XVII to anchor roots and preserve stem cells longevity.
From root to tip, it fortifies follicles and fibers, tames frizz, reduces brittleness, and boosts volume, softness, and detangling, for stronger, healthier, more resilient hair.
RESULTS:
✓ +40% detangling (easier combing) in one application
✓ Immediate frizz control
✓ -43.8% hair shedding in 28 days
✓ 91% of volunteers showed a notably/greater hair volume after one month
✓ 86% of volunteers noticed immediate smoothness, repair, sleekness, & less frizz
✓ 96% of volunteers felt their hair was stronger, revitalized, & less brittle after 28 days
FRAG-BRILLIN™
The era of cellasticity
Fibrillin microfibrils are key for skin structural integrity, flexibility and remodeling, therefore their degradation results in wrinkles and sagging.
Frag-Brillin remastered™ is a biomimetic fragment of human fibrillin-1 which rebuilds elastic resilience stimulating fibrillin microfibrils and elastic fibers formation. It also promotes cellasticity and skin remodeling. It instantly improves firmness and elasticity in both face and body and immediately smoothes wrinkles.
RESULTS:
✓ 82% of volunteers showed firmer skin (56 days)
✓ Up to 17% more elasticity in face (28 days)
✓ All the volunteers increased the elasticity in their face, arms & legs (28 days)
✓ Up to 17% firmness in face (1 h)
✓ -6.8% roughness in cheeks (1 h)
✓ -13.8% wrinkle depth in crow’s feet (1 h)
COL-4-FRAG™
Weaving the collagen net
Col-4-Frag remastered™ from Remastered Fragments line, is a sustainable and biomimetic to human collagen IV fragment produced by Wild plants as biofactories through vertical farming.
Col-4-Frag remastered™ acts on the collagen IV net by intervening in its synthesis & anchoring thanks to perlecan & collagen type VII. This helps to form more interdigitations in the DEJ (Dermo-Epidermal Junction), promoting the nourishment and tightness of dermis and epidermis. As a result, you can enjoy a smooth and flawless skin with less wrinkles and dark spots.
RESULTS:
✓ -6% crow’s feet wrinkle volume in 1 hour
✓ Up to 28% less crow’s feet wrinkle depth in 28 days
✓ -21% neck wrinkle volume in 56 days
✓ +15% décolleté firmness in 7 days
✓ -15% décolleté dark spots perimeter in 28 days
ANARGY™
Let your eyelashes bloom
Anargy™ contains proteins that are able to nourish, protect and detoxify hair root helping to reactivate hair growth cycle for a redensifying and strengthening of hair locks.
Naturally amplifies, extends, lifts and curls your eyelashes letting them bloom.
RESULTS:
✓ Up to 21,480 new hairs in the whole scalp in 150 days
✓ Up to 76% less hair loss after combing and washing in 150 days
✓ 95% volunteers with longer and fuller eyelashes after 30 days
EPITENSIVE™ EVO
Structural protein booster
Epitensive™ EVO is a biomimetic protein transiently expressed through the Wild plants as biofactories technology grown in vertical farming. It is a structural protein booster that reignites cell metabolism and turnover in the epidermis and dermis.
Epitensive™ EVO revitalizes the skin, restoring its glow, enhancing firmness and elasticity, and provides an instant smoothing of wrinkles and a rejuvenated appearance.
RESULTS
✓ -9.6% and -9.3% wrinkle depth and volume in 1 h
✓ -3.5 and -4.8 years old appearance based on a wrinkle big database after 1 h and 28 days
✓ Up to 26% less roughness in 1 h
✓ Up to 29% and 25% more elasticity and firmness after one week
✓ +30.3% gloss in only 1h
✓ +25% youth/beauty index after 28 days (self-assessment of 10 beauty points)
Col-Frag Remastered™
A new collagen era
Col-Frag remastered™ acts as a building block and booster for collagen synthesis, and tightens the dermis and epidermis while preventing senescence.
It revealed a synergistic effect and a superior efficacy to Ascorbyl Glucoside in reducing wrinkles, providing a facelift and enhancing skin brightness.
RESULTS
✓ Up to 21% wrinkle length after 30 minutes
✓ -11% wrinkle length in 28 days
✓ -19% wrinkle depth after 30 minutes
✓ -24% wrinkle depth in 100% volunteers at 28 days
✓ -2.54 mm lifting in 85% volunteers after 28 days
✓ +25% brightness in 85% volunteers after 1 month
EPITENSIVE™
Intensive anti-aging plant - EGF
Epitensive™ contains plant-Epidermal Growth Factor (plant-EGF), a protein able to activate the ERK and AKT pathways.
These paths are involved in protein synthesis and cellular regeneration to provide mature skin with the right extracellular matrix content and regenerative capacity lost with age.
RESULTS
✓ Up to a 39% and 32% reduction in the volume and depth of wrinkles after 28 days
✓ Up to 10 years of physiological skin rejuvenation after 28 days
PUREOXIN™
More than an illuminating plant-TRX1
Pureoxin™ contains plant-Thioredoxin-1 (plant-TRX-1), a multifunctional protein able to protect the skin from inflammaging and photoagingcaused by ROS, MMP-9 and TNFα induced by radiation. Moreover, it can decrease the content of superficial melanin helping to lighten and illuminate skin tone.
RESULTS
✓ Up to 74% reduction of superficial melanin after 56 days
✓ –3.8-fold UV damage vs placebo in 28 days
RENESEED™
The seed of youth
Reneseed™ contains plant-Transforming Growth Factor Beta-2 (plant TGFβ2), the seed of youth of our skin, as it is implicated in the extracellular matrix protein synthesis and the production of epidermal lipids, improving the skin integrity and protection. It has a retinol and retinoic acid-like activity in terms of collagen I production efficacy.
Reneseed™ helps your skin to recover its own beauty that is sleeping inside with its broad-spectrum antiaging properties and pore size minimizer efficacy for night but also for day treatments.
RESULTS
✓ -16%, -11% and -14% wrinkle count, volume and depth, respectively, in 28 days
✓ Up to 42% increase of skin radiance in 28 days
✓ Up to 44% smaller pore size in 28 days
✓ +11% and +6% firmness and elasticity, respectively, in 28 days
✓ Up to 28% more hydration in 28 days
SCELLEYE™
Detoxifing eye contour plant-IGF1
Scelleye™ is a biomimetic Insulin-like Growth Factor-1 (plant-IGF1) produced in Wild plants as biofactories technology through vertical farming. The IGF-1 is a protein able to restore the activity of the skin basal layers, as well as to activate the proteasome and decrease carbonylation, for an effective clearance of damaged proteins.
RESULTS
✓ –2.8% melanin in dark circles after 7 days
✓ Up to 54% and 36% reduction in wrinkle volume and depth after 28 days
TIMLOG™
Redefining the past
Timlog™ acts as a guardian for skin’s dermochronology, repairing dermal solar scarsredefining the past.
RESULTS
✓ +127% fibromodulinvs basal, which is key inscarless repair
✓ +8% skin isotropyin 7 days
WISEGRADE™
Embrace the wise gradient
Wisegrade™ is produced in Wild plants as biofactories technology which allows the production of biomimetic proteins or protein fragments through vertical farming. Wisegrade™ helps to regulate the amount of desired grey, in a natural non-damaging way.
It improves endogenous antioxidant rebalancing, redox homeostasis, protects the stem cell pool, reactivates the melanogenesis cycle and reinforces melanosome integrity.
Wisegrade™provides antioxidant protection, enhances gloss and allows you to regulate the amount of grey hair.
RESULTS
✓ -17% grey hair ratio after 4 months
✓ Up to 34% decrease of grey hair ratioin 4 months
✓+18% antioxidant protection in 85% volunteers in 3 months
✓+12% gloss in 65% of volunteers in 2 months
